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1

OP0193 Pyrin and PSTPIP1, Mutated in FMF, PAPA-, and PAMI Syndrome, are Involved in the Hypersecretion of Alarmins MRP8/14

Fassl, S.K., Holzinger, D., Vogl, T., Gattorno, M., Omenetti, A., Chae, J.J., Aksentijevich, I., Austermann, J., Roth, J.

Journal:

Annals of the Rheumatic Diseases

Year:

2015

Language:

english

File:

PDF, 65 KB

english, 2015

2

Principles of Inflammation for the Pediatrician

Omenetti, Alessia, Chiesa, Sabrina, Gattorno, Marco

Journal:

Pediatric Clinics of North America

Year:

2012

Language:

english

File:

PDF, 1.04 MB

english, 2012

3

From bench to bedside and back again: translational research in autoinflammation

Holzinger, Dirk, Kessel, Christoph, Omenetti, Alessia, Gattorno, Marco

Journal:

Nature Reviews Rheumatology (formerly Nature Clinical Practice Rheumatology)

Year:

2015

Language:

english

File:

PDF, 875 KB

english, 2015

4

Chronic Infantile Neurological Cutaneous and Articular (CINCA) syndrome: a review

Finetti, Martina, Omenetti, Alessia, Federici, Silvia, Caorsi, Roberta, Gattorno, Marco

Journal:

Orphanet Journal of Rare Diseases

Year:

2016

Language:

english

File:

PDF, 1.78 MB

english, 2016

5

Role for hedgehog pathway in regulating growth and function of invariant NKT cells

Wing-Kin Syn, Rafal P. Witek, Stuart M. Curbishley, Youngmi Jung, Steve S. Choi, Barbara Enrich, Alessia Omenetti, Kolade M. Agboola, Caitlin M. Fearing, Herbert Tilg, David H. Adams, Anna Mae Diehl

Journal:

European Journal of Immunology

Year:

2009

Language:

english

File:

PDF, 445 KB

english, 2009

6

Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production

Alessia Omenetti, Wing-Kin Syn, Youngmi Jung, Heather Francis, Alessandro Porrello, Rafal P. Witek, Steve S. Choi, Liu Yang, Marlyn J. Mayo, M. Eric Gershwin, Gianfranco Alpini, Anna Mae Diehl

Journal:

Year:

2009

Language:

english

File:

PDF, 620 KB

english, 2009

7

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

Rafal P. Witek, W. Carl Stone, F. Gamze Karaca, Wing-Kin Syn, Thiago A. Pereira, Kolade M. Agboola, Alessia Omenetti, Youngmi Jung, Vanessa Teaberry, Steve S. Choi, Cynthia D. Guy, John Pollard, Peter

Journal:

Year:

2009

Language:

english

File:

PDF, 2.57 MB

english, 2009

8

Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice

Begoña Ochoa, Wing-Kin Syn, Igotz Delgado, Gamze F. Karaca, Youngmi Jung, Jiangbo Wang, Ana M. Zubiaga, Olatz Fresnedo, Alessia Omenetti, Marzena Zdanowicz, Steve S. Choi, Anna Mae Diehl

Journal:

Year:

2010

Language:

english

File:

PDF, 765 KB

english, 2010

9

Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease

Wing-Kin Syn, Ye Htun Oo, Thiago A. Pereira, Gamze F. Karaca, Youngmi Jung, Alessia Omenetti, Rafal P. Witek, Steve S. Choi, Cynthia D. Guy, Caitlin M. Fearing, Vanessa Teaberry, Fausto E.L. Pereira,

Journal:

Year:

2010

Language:

english

File:

PDF, 2.31 MB

english, 2010

10

Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells

Steve S. Choi, Rafal P. Witek, Liu Yang, Alessia Omenetti, Wing-Kin Syn, Cynthia A. Moylan, Youngmi Jung, Gamze F. Karaca, Vanessa S. Teaberry, Thiago A. Pereira, Jiangbo Wang, Xiu-Rong Ren, Anna Mae

Journal:

Year:

2010

Language:

english

File:

PDF, 1.58 MB

english, 2010

11

Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia

Alessia Omenetti, Lee M. Bass, Robert A. Anders, Maria G. Clemente, Heather Francis, Cynthia D. Guy, Shannon McCall, Steve S. Choi, Gianfranco Alpini, Kathleen B. Schwarz, Anna Mae Diehl, Peter F. Whi

Journal:

Year:

2011

Language:

english

File:

PDF, 11.01 MB

english, 2011

12

Characterization of tonsil infiltration and gene expression profile of innate sensors in PFAPA patients

S Chiesa, MA Pelagatti, M Finetti, I Prigione, R Caorsi, D Lasiglié, R D’Agostino, A Sementa, A Omenetti, E Traggiai, A Martini, M Gattorno

Journal:

Pediatric Rheumatology

Year:

2011

Language:

english

File:

PDF, 82 KB

english, 2011

13

Significance of I313V mutation of NLPR3 gene in two pediatric patients

A Omenetti, R Antona, R Gallizzi, M Alessio, M Finetti, S Carta, A Rubartelli, A Martini, M Gattorno

Journal:

Pediatric Rheumatology

Year:

2011

Language:

english

File:

PDF, 93 KB

english, 2011

14

Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice

Wing-Kin Syn, Liu Yang, Dian Jung Chiang, Yue Qian, Youngmi Jung, Gamze Karaca, Steve S. Choi, Rafal P. Witek, Alessia Omenetti, Thiago A. Pereira, Anna Mae Diehl

Journal:

Liver International

Year:

2009

Language:

english

File:

PDF, 886 KB

english, 2009

15

Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma

Pereira, Thiago de Almeida, Witek, Rafal P, Syn, Wing-Kin, Choi, Steve S, Bradrick, Shelton, Karaca, Gamze F, Agboola, Kolade M, Jung, Youngmi, Omenetti, Alessia, Moylan, Cynthia A

Journal:

Laboratory Investigation

Year:

2010

Language:

english

File:

PDF, 1.43 MB

english, 2010

16

Hedgehog-mediated mesenchymal–epithelial interactions modulate hepatic response to bile duct ligation

Omenetti, Alessia, Yang, Liu, Li, Yin-Xiong, McCall, Shannon J, Jung, Youngmi, Sicklick, Jason K, Huang, Jiawen, Choi, Steve, Suzuki, Ayako, Diehl, Anna Mae

Journal:

Laboratory Investigation

Year:

2007

Language:

english

File:

PDF, 924 KB

english, 2007

17

Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice

Fleig, Susanne V, Choi, Steve S, Yang, Liu, Jung, Youngmi, Omenetti, Alessia, VanDongen, Hendrika M, Huang, Jiawen, Sicklick, Jason K, Diehl, Anna Mae

Journal:

Laboratory Investigation

Year:

2007

Language:

english

File:

PDF, 829 KB

english, 2007

18

Fate-Mapping Evidence That Hepatic Stellate Cells Are Epithelial Progenitors in Adult Mouse Livers

Liu Yang, Youngmi Jung, Alessia Omenetti, Rafal P. Witek, Steve Choi, Hendrika M. Vandongen, Jiawen Huang, Gianfranco D. Alpini, Anna Mae Diehl

Journal:

Year:

2008

Language:

english

File:

PDF, 3.47 MB

english, 2008

19

The role of Hedgehog signaling in fibrogenic liver repair

Steve S. Choi, Alessia Omenetti, Wing-Kin Syn, Anna Mae Diehl

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2011

Language:

english

File:

PDF, 542 KB

english, 2011

20

CS10-5. Deficient IL-1 Receptor antagonist production by monocytes from patients carrying mutations in the NLRP3 gene

Anna Rubartelli, Laura Delfino, Alessia Omenetti, Marco Gattorno, Sonia Carta

Journal:

Year:

2011

Language:

english

File:

PDF, 38 KB

english, 2011

21

Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells

Liu Yang, Ying Wang, Hua Mao, Susanne Fleig, Alessia Omenetti, Kevin D. Brown, Jason K. Sicklick, Yin-Xiong Li, Anna Mae Diehl

Journal:

Journal of Hepatology

Year:

2008

Language:

english

File:

PDF, 426 KB

english, 2008

22

Hedgehog signaling in the liver

Alessia Omenetti, Steve Choi, Gregory Michelotti, Anna Mae Diehl

Journal:

Journal of Hepatology

Year:

2011

Language:

english

File:

PDF, 920 KB

english, 2011

23

[354] THE SELECTIVE INHIBITION OF THE NA+/H+ EXCHANGER BY CARIPORIDE INCREASES THE ANTINEOPLASTIC EFFECT OF GEMCITABINE IN HUMAN CHOLANGIOCARCINOMA CELLS THROUGH MODULATION OF PHARMACORESISTANCE

A. Di Sario, A. Omenetti, C. Candelaresi, E. Bendia, S. Cascinu, H.W. Kleemann, G. Fava, A. Benedetti

Journal:

Journal of Hepatology

Year:

2007

Language:

english

File:

PDF, 138 KB

english, 2007

24

[353] ADHESION OF IN VITRO GENERATED DENDRITIC CELLS TO HUMAN HEPATIC ENDOTHELIUM UNDER CONDITIONS OF FLUID FLOW

S.M. Curbishley, A.I. Aspinall, J. Youster, W.K. Lai, D.H. Adams, A. Di Sario, A. Omenetti, C. Candelaresi, E. Bendia, S. Cascinu, H.W. Kleemann, G. Fava, A. Benedetti

Journal:

Journal of Hepatology

Year:

2007

Language:

english

File:

PDF, 138 KB

english, 2007

25

75 MYOFIBROBLASTS PROVIDE HEDGEHOG PARACRINE SIGNALS THAT DRIVE CHOLANGIOCYTES TO RECRUIT NKT CELLS TO PORTAL TRACTS

A. Omenetti, W.-K. Syn, Y. Jung, R.P. Witek, S.S. Choi, A.M. Diehl

Journal:

Journal of Hepatology

Year:

2009

Language:

english

File:

PDF, 70 KB

english, 2009

26

A Model of Insulin Resistance and Nonalcoholic Steatohepatitis in Rats: Role of Peroxisome Proliferator-Activated Receptor-α and n-3 Polyunsaturated Fatty Acid Treatment on Liver Injury

Gianluca Svegliati-Baroni, Cinzia Candelaresi, Stefania Saccomanno, Gianna Ferretti, Tiziana Bachetti, Marco Marzioni, Samuele De Minicis, Liliana Nobili, Renata Salzano, Alessia Omenetti, Deborah Pac

Journal:

The American Journal of Pathology

Year:

2006

Language:

english

File:

PDF, 1.63 MB

english, 2006

27

The anti-fibrotic effect of pirfenidone in rat liver fibrosis is mediated by downregulation of procollagen α1(I), TIMP-1 and MMP-2

A. Di Sario, E. Bendia, G. Macarri, C. Candelaresi, S. Taffetani, M. Marzioni, A. Omenetti, S. De Minicis, L. Trozzi, A. Benedetti

Journal:

Digestive and Liver Disease

Year:

2004

Language:

english

File:

PDF, 469 KB

english, 2004

28

Hepatoprotective and antifibrotic effect of a new silybin–phosphatidylcholine–Vitamin E complex in rats

A. Di Sario, E. Bendia, S. Taffetani, A. Omenetti, C. Candelaresi, M. Marzioni, S. De Minicis, A. Benedetti

Journal:

Digestive and Liver Disease

Year:

2005

Language:

english

File:

PDF, 555 KB

english, 2005

29

Selective inhibition of ion transport mechanisms regulating intracellular pH reduces proliferation and induces apoptosis in cholangiocarcinoma cells

A. Di Sario, E. Bendia, A. Omenetti, S. De Minicis, M. Marzioni, H.W. Kleemann, C. Candelaresi, S. Saccomanno, G. Alpini, A. Benedetti

Journal:

Digestive and Liver Disease

Year:

2007

Language:

english

File:

PDF, 776 KB

english, 2007

30

27 The antifibrotic effect of pirfenidone in rat liver fibrosis is mediated by downregulation of procollagen α1(1), TIMP-1 and MMP-2

E. Bendia, A. Di Sario, C. Candelaresi, S. Taffetani, A. Omenetti, L. Trozzi, A. Fava, A. Benedetti

Journal:

Digestive and Liver Disease

Year:

2003

Language:

english

File:

PDF, 159 KB

english, 2003

31

OC3.05.2 LIVER STIFFNESS CORRELATES WITH THE DEGREE OF INTESTINAL DAMAGE IN PATIENTS WITH CELIAC DISEASE

A. Di Sario, A. Damiani, A. Suzuki, M. Marzioni, M. Lucioni, A. Omenetti, E. Bendia, A. Benedetti

Journal:

Digestive and Liver Disease

Year:

2008

Language:

english

File:

PDF, 66 KB

english, 2008

32

Accumulation of Hedgehog-Responsive Progenitors Parallels Alcoholic Liver Disease Severity in Mice and Humans

Youngmi Jung, Kevin D. Brown, Rafal P. Witek, Alessia Omenetti, Liu Yang, Margon Vandongen, Richard J. Milton, Ian N. Hines, Richard A. Rippe, Laurent Spahr, Laura Rubbia–Brandt, Anna Mae Diehl

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 5.44 MB

english, 2008

33

Liver Cell–Derived Microparticles Activate Hedgehog Signaling and Alter Gene Expression in Hepatic Endothelial Cells

Rafal P. Witek, Liu Yang, Renshui Liu, Youngmi Jung, Alessia Omenetti, Wing–Kin Syn, Steve S. Choi, Yeiwon Cheong, Caitlin M. Fearing, Kolade M. Agboola, Wei Chen, Anna Mae Diehl

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 3.59 MB

english, 2009

34

Hedgehog-Mediated Epithelial-to-Mesenchymal Transition and Fibrogenic Repair in Nonalcoholic Fatty Liver Disease

Wing–Kin Syn, Youngmi Jung, Alessia Omenetti, Manal Abdelmalek, Cynthia D. Guy, Liu Yang, Jiangbo Wang, Rafal P. Witek, Caitlin M. Fearing, Thiago A. Pereira, Vanessa Teaberry, Steve S. Choi, J. Conde

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 4.32 MB

english, 2009

35

PReS-FINAL-2324: PAPA syndrome clinical spectrum and IL-1Β release

Omenetti, A, Caorsi, R, Carta, S, Delfino, L, Penco, F, Pastorino, C, Schena, F, Martini, A, Rubartelli, A, Gattorno, M

Journal:

Pediatric Rheumatology

Year:

2013

Language:

english

File:

PDF, 102 KB

english, 2013

36

T1964 Gene Expression Profiles During Activation of Human Hepatic Stellate Cells Suggest an Epithelial-to-Mesenchymal Transition-Like Process

Moylan, Cynthia A., Choi, Steve S., Acharya, Chaitanya R., Syn, Wing-Kin, Omenetti, Alessia, Jung, Youngmi, Sudan, Debra L., Muir, Andrew J., Potti, Anil, Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 48 KB

english, 2010

37

P89 HEAT SHOCK FACTOR 1 (HSF1) IS DOWNREGULATED IN RADIOFREQUENCY ABLATED MICE WITH SECONDARY LIVER CANCER PRETREATED WITH NANOLIPOSOMAL shRNA-HSF1

Zanieri, F., Rombouts, K., Carloni, V., Omenetti, S., Tosoratti, N., Cassarino, S., Amabile, C., Velandy, S.S.S., Kester, M., Pinzani, M.

Journal:

Journal of Hepatology

Year:

2014

Language:

english

File:

PDF, 55 KB

english, 2014

38

P287 HEPATIC C6-CERAMIDE NANOLIPOSOMAL UPTAKE AFFECTS MCD-INDUCED NASH IN VIVO VIA ALTERATIONS IN PROLIFERATIVE, FIBROTIC AND OXIDATIVE STRESS SIGNALING PATHWAYS

Zanieri, F., Omenetti, S., Cavallaro, D., Galastri, S., Madiai, S., Luong, T.V., Velandy, S.S.S., Fox, T., Kester, M., Rombouts, K., Pinzani, M.

Journal:

Journal of Hepatology

Year:

2014

Language:

english

File:

PDF, 65 KB

english, 2014

39

S1926 Increased Short-Term Risk for Liver-Related Mortality Parallels Accumulation of Hedgehog-Responsive Progenitors in Patients with Alcoholic Steatohepatitis

Jung, Youngmi, Brown, Kevin D., Witek, Rafal P., Omenetti, Alessia, Yang, Liu, Vandongen, Hendrika, Milton, Richard J., Hines, Ian, Rippe, Richard A., Spahr, Laurent, Rubbia-Brandt, Laura, Diehl, Anna

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 117 KB

english, 2008

40

343 Myofibroblasts Promote the Growth of Biliary Tree During Cholestatic Liver Injury By Suppressing Tryptophan Hydroxylase 2 (TPH2) Expression and Serotonin Secretion in Neighboring Cholangiocytes

Omenetti, Alessia, Yang, Liu, Gainetdinov, Raul R., Choi, Steve S., Witek, Rafal P., Jung, Youngmi, Syn, Wing-Kin, Chen, Wei, Caron, Marc G., Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 51 KB

english, 2009

41

89 Sustained Activation of RAC1 Enhances Hedgehog-Mediated Epithelial-Mesenchymal Transition in Mice with Chronic Liver Injury

Choi, Steve S., Witek, Rafal P., Omenetti, Alessia, Yang, Liu, Syn, Wing-Kin, Jung, Youngmi, Sicklick, Jason K., Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 51 KB

english, 2009

42

1 Specific Inhibition of Ikkβ in Hepatocytes Induces Proliferation of Liver Progenitors in Injured Livers

Jung, Youngmi, Witek, Rafal P., Syn, Wing-Kin, Choi, Steve S., Omenetti, Alessia, Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 50 KB

english, 2009

43

685 Glial Fibrillary Acidic Protein(+) Progenitors Regenerate Adult Livers

Yang, Liu, Jung, Youngmi, Huang, Jiawen, Omenetti, Alessia, Witek, Rafal P., Choi, Steve S., Alpini, Gianfranco, Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 84 KB

english, 2008

44

T1960 Leptin Activates Hedgehog Pathway Signaling and Promotes Myofibroblastic Transition and Accumulation in Rat Hepatic Stellate Cells

Choi, Steve S., Syn, Wing-Kin, Karaca, Gamze F., Omenetti, Alessia, Wang, Xiaoling, Jung, Youngmi, Teaberry, Vanessa S., Moylan, Cynthia A., Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 51 KB

english, 2010

45

M1577 Culture Activation of Murine Hepatic Stellate Cells Involves Hedgehog Pathway Activation and Epithelial-to-Mesenchymal Transitions

Choi, Steve S., Omenetti, Alessia, Yang, Liu, Witek, Rafal P., Brown, Kevin D., Vazquez-Chantada, Mercedes, Huang, Jiawen, Jung, Youngmi, Syn, Wing-Kin, Sicklick, Jason K., Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 72 KB

english, 2008

46

T1821 Liver-Derived Microparticles Carry Biologically-Active Hedgehog Morphogens in Blood and Bile

Witek, Rafal P., Liu, Renshui, Yang, Liu, Jung, Youngmi, Brown, Kevin, Omenetti, Alessia, Vazquez-Chantada, Mercedes, Syn, Wing-Kin, Choi, Steve S., Huang, Jiawen, Chen, Wei, Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 68 KB

english, 2008

47

M1582 Hedgehog Signaling Pathway in Primary Human Hepatic Stellate Cells

Brown, Kevin D., Oben, Jude A, Sigala, Barbara, Yang, Liu, Omenetti, Alessia, Sicklick, Jason K., Vandongen, Hendrika, Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 63 KB

english, 2008

48

S1585 Myofibroblast-Derived Soluble Factors Upregulate Chemokine Gene Expression in Neighboring Cholangiocytes

Omenetti, Alessia, Porrello, Alessandro, Syn, Wing-Kin, Choi, Steve S., Jung, Youngmi, Yang, Liu, Brown, Kevin D., Witek, Rafal P., Vandongen, Hendrika, Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 61 KB

english, 2008

49

Immunosuppressive monocytes: possible homeostatic mechanism to restrain chronic intestinal inflammation

Kurmaeva, E., Bhattacharya, D., Goodman, W., Omenetti, S., Merendino, A., Berney, S., Pizarro, T., Ostanin, D. V.

Journal:

Journal of Leukocyte Biology

Year:

2014

Language:

english

File:

PDF, 2.17 MB

english, 2014

50

Myristoylated Alanine-Rich protein Kinase C Substrate (MARCKS) expression modulates the metastatic phenotype in human and murine colon carcinoma in vitro and in vivo

Rombouts, Krista, Carloni, Vinicio, Mello, Tommaso, Omenetti, Sara, Galastri, Sara, Madiai, Stefania, Galli, Andrea, Pinzani, Massimo

Journal:

Year:

2013

Language:

english

File:

PDF, 2.08 MB

english, 2013